The Nantahala River is a river in western North Carolina in the United States, within the Nantahala National Forest, and near the Great Smoky Mountains National Park. Two-lane U.S. Highway 19/74 runs along the river, picnic areas dotting the route. In 1839, this was an unimproved large path, part of what became known as the Trail of Tears as the Cherokā¦The Nantahala River is a river in western North Carolina in the United States, within the Nantahala National Forest, and near the Great Smoky Mountains National Park. Two-lane U.S. Highway 19/74 runs along the river, picnic areas dotting the route. In 1839, this was an unimproved large path, part of what became known as the Trail of Tears as the Cherokee people were forcibly removed from their homelands in this region to west of the Mississippi River and Indian Territory.