Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, ...

A team of researchers has developed a laboratory model that recapitulates the pathological aggregation of TAR DNA-binding protein 43 (TDP-43), a hallmark of amyotrophic lateral sclerosis (ALS) and ...

Inclusion bodies formed of ubiquitinated proteins in the cytoplasm or nucleus of CNS neurons are a common feature of neurodegenerative disorders. Neumann et al. have identified the ubiquitinated ...

"Endothelial TDP-43 depletion disrupts core blood–brain ... Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD)—shared fundamental similarities ...

The study, “Endothelial TDP-43 Depletion Disrupts Core Blood ... disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD)—shared fundamental similarities that ...

ProMIS Neurosciences (PMN) announced plans to deliver virtual oral presentations at the 2025 Alzheimer’s and Parkison’s Disease International ...

The study, "Endothelial TDP-43 Depletion Disrupts Core Blood ... disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD)-shared fundamental similarities that set ...

The study, "Endothelial TDP-43 Depletion Disrupts Core Blood ... disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) -- shared fundamental similarities that ...