Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

When they tested the therapy in mice lacking this receptor, the benefits disappeared, confirming that bile acid metabolism is essential for healing. To further validate their findings, they ...

Conclusion: The low blood levels of LCA found indicate a normal metabolism of this bile acid in fetuses with EHBA. The increased levels of CA and CDCA in the infants with this disease can be due ...

When they tested the therapy in mice lacking this receptor, the benefits disappeared, confirming that bile acid metabolism is essential for healing. To further validate their findings, they ...

Age-related neurodegenerative disorders — motor neuron diseases, demyelinating diseases, Alzheimer’s disease, and other proteinopathies — are at an ‘inflection point.’ ...

EPFL researchers discover that Clostridium scindens can restore bile acid balance, aiding gut healing and offering a ...

Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary ...