Diseases such as covid-19 and influenza can be fatal due to an overreaction of the body’s immune system called a cytokine storm. Cytokines are small proteins released by many different cells in ...

Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both ...

With more cytokine-based drugs entering clinical trials and novel combination and masking technologies being used, there is a growing need for experts to discuss, understand, and build on the ...

This paradigm shift highlights a key role for the interleukin (IL)-23 cytokine, rather than the previous emphasis on IL-12, as the driving force behind the persistent inflammatory reaction.