1 Introduction. Many of the bacteria of the Bacillota (formerly Firmicutes) and Actinomycetota (formerly Actinobacteria), herein referred to collectively under their previous designation of ...

For over 50 y, it has been commonly accepted that the metabolic intermediates in the heme biosynthetic pathway are conserved among all organisms, with the one variation being the manner by which the ...

To determine how knockdown of ABCB10 reduces heme content, we measured the levels of enzymes catalyzing each of the 8 steps in the heme biosynthesis pathway. The mRNA and protein levels of ALAS1, the ...

During RBC maturation, heme metabolism genes are robustly upregulated (Chung et al., 2012; Nilsson et al., 2009; Yien et al., 2014). Not surprisingly, mutations in these genes are most commonly ...

New research by Christoph Handschin and colleagues reveals a missing molecular link that helps explain the mystery.1 These researchers found that fasting increases the level of a protein, proliferator ...

Parasites retain a heme biosynthesis pathway but do not require its activity during infection of heme-rich erythrocytes, where they can scavenge host heme to meet metabolic needs. Nevertheless, heme ...

It has been accepted dogma that eukaryotes and heme-synthesizing bacteria use the same metabolic intermediates in their heme synthesis pathways, where protoporphyrin is the final intermediate into ...