More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...

About 65% of melanoma patients do not respond to immunotherapy. New work by the team of Prof. Max Mazzone (VIB-KU Leuven ...

About 65% of melanoma patients do not respond to immunotherapy. New work by the team of Prof. Max Mazzone (VIB-KU Leuven ...

This response is general and nonspecific. If pathogens manage to bypass the innate immune system, macrophages will attack them. Macrophages will also produce substances called cytokines ...

Researchers at the University of Cologne have found that mRNA-based COVID-19 vaccines have a lasting impact on the innate ...

Fruits and plant extracts contain bioactive compounds that can help treat or prevent diseases. To characterize and understand ...

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against potential ...

The human immune system has two lines of defense. The innate immune system acts quickly and non-specifically to detect and fight infections; the slower, adaptive immune response recognizes and targets ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Because the innate immune response is more general ... We recently studied a key enzyme, ORF2p, produced by LINE-1 that is essential for its replication. By understanding the structure of ORF2p and ...

These findings expand our understanding of the body's innate defenses and offer new ... a life-threatening condition ...

Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular mechanisms underlying this interplay are not fully understood. This study ...