Reference: Tuck JR, Dunlap LE, Khatib YA, et al. Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential. Proc Nat Acad Sci USA . 2025. doi: 10.1073/pnas.2416106122 This ...

Lysergic acid diethylamide, or LSD, is best known for its powerful mind-altering effects. But in recent years, researchers have discovered that LSD and similar compounds can also promote ...

JRT has the same molecular weight and general shape as LSD. But that small atomic switch made it behave very differently. It became highly selective for the 5-HT2A receptor—the key site for ...

Psychedelic drugs, such as lysergic acid diethylamide (LSD), can increase neuronal growth, which can have therapeutic effects for conditions such as schizophrenia. However, such drugs can induce ...

To design the drug, dubbed JRT, researchers flipped the position of just two atoms in LSD’s molecular structure. The chemical flip reduced JRT’s hallucinogenic potential while maintaining its ...

Scientists Tweaked LSD’s Molecular Structure and Created a Wild New Brain Drug This new compound could be a game changer. May 17, 7:30 AM EDT / Victor Tangermann ...

The new molecule could lead to treatments for mental illnesses like depression and schizophrenia, neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease, traumatic brain ...

NPR science podcast Short Wave brings us the stories of how Fiddler crabs drum their mating songs into the sand, growing chicken nuggets in the lab, and a drug like LSD -- without the trip.

UC Davis researchers developed JRT, a modified version of LSD that promotes neuroplasticity without hallucinogenic effects. Tested in mice, JRT enhanced brain connectivity, showed antidepressant ...

UC Davis researchers have developed a new, neuroplasticity-promoting drug closely related to LSD that harnesses the psychedelic’s therapeutic power with reduced hallucinogenic potential.