The typical starting dose of MTX for PsA is 5 to 10 milligrams (mg) per week for the first week or two. Depending on your response, the doctor will gradually increase the dose to reach 15 to 25 mg ...

However, preliminary evidence has revealed the association of long-chain MTX polyglutamates 3–5 with gastrointestinal and liver toxicity. Intracellular folate concentrations may also contribute ...

High GerdQ scores were associated with increased disease activity scores and lower weekly methotrexate dosages among patients ... A total of 452 patients (mean age, 65.5 years; 72.3% women) were ...

However, patients were excluded if they had discontinued therapy with ≥15 mg per week methotrexate owing to an inadequate response or toxic effects. Although the investigators acknowledge the ...

This was a 7-center study of 76 chronically-active Crohn's patients, all of whom had already achieved successful steroid-free remissions on 16-24 weeks of methotrexate 25 mg intramuscularly per week.