Most cells in the body send out little messengers called extracellular vesicles that carry proteins, lipids, and other ...

A protein called coat protein II (COPII; green) forms vesicles that transport from the endoplasmic reticulum (ER) to the Golgi. A different protein called coat protein I (COPI; red) forms vesicles ...

The targeting of transport vesicles to the correct membrane destination involves a much larger set of proteins than anticipated and several layers of protein–protein interactions. The process of ...

Cells can also send out packages called exosomes, lipid vesicles that bubble off from the cell membrane. But for about 20 ...

Membrane protein trafficking in eukaryotes relies on dozens of protein complexes that recruit cargoes, drive vesicle budding, and catalyze vesicle fusion. While the biological roles of these membrane ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into the ...

These extracellular vesicles (EVs), including exosomes and microvesicles, contain a multi-molecular cargo of proteins, nucleic acids, lipids and metabolites. Together with the number of EVs, this ...

A major focus of research is on the COPII protein machinery responsible for synthesis of ER-derived transport vesicles. We are exploring the mechanisms utilized by COPII to segregate folded protein ...