Researchers have identified a set of geological reaction conditions that may have catalysed life on Earth. Researchers have discovered a plausible evolutionary setting in which nucleic acids – the ...

This useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1. The authors propose that ...

Changes in neural activity thought to reflect brain aging may be partly influenced by age-dependent signals ‘leaking’ from the heart.

This important work shows how a simple geophysical setting of gas flow over a narrow channel of water can create a physical environment that leads to the isothermal replication of nucleic acids. The ...

In sum, odors initiate feeding behavior in Drosophila.

A core task in single-cell data analysis is recovering the latent dimensions encoding the genetic and epigenetic landscapes inhabited by cell types and lineages. However, consensus is lacking for ...

A complex extracted from the amniotic membrane in humans reduces post-surgical pain in mice by directly inhibiting pain-sensing neurons.

A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).

A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.

Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue ...

A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and ...

However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...