This important study presents a transcriptomic analysis of enterochromaffin cells in the intestine. The evidence supporting the authors' claims is solid, although the functional analysis is focused on ...

Neurons are cells in the body that are responsible for transmitting electrical signals through the nervous system. Different types of neurons affect the ability to move, which begins as an impulse, or ...

Dysregulated serotonin signaling, driven by altered enterochromaffin cell activity and abnormal serotonin reuptake, contributes to gut-brain axis dysfunction and sensitizes peripheral nerves, leading ...

Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Like other types of cancer, carcinomas are abnormal cells that ...

This was a mighty challenge. The cells kept dying. Paleontologist Kyoko Hagino of Kochi University tried for twelve years until she finally cracked it with a cousin of the original organism.

scRNA-seq identifies distinct intestinal enterochromaffin (EC) cell clusters. (a,b) Dual IF staining of 5-HT and GFP (representing Tph1) (a) and their quantification ...

Previous studies have demonstrated that TRPC4 contributes to the Ca 2+-permeable responses to GPCR signaling in a variety of cells, including the gut epithelium enterochromaffin cells, adrenal ...

The “ON” mechanism is constituted in the gut by enterochromaffin cells and serotonergic neurons of the ENS, while in the CNS, 5-HT is produced only by serotonergic neurons. The primary source of 5-HT ...