Figure 6: A model for the TGR5 ligand binding pocket. Bile-acid-binding resins that decrease bile-acid pool size. Bile-acid-binding resins, such as cholestyramine and colestimide, form a complex ...

Possible side effects of Nexlizet, from more to less common, may include: Another alternative to statins is bile acid-binding resins, or sequestrants. These drugs work by binding to the bile in ...

A study shows that the semi-synthetic bile acid NorUDCA inhibits in the intestine the formation of pro-inflammatory T helper 17 cells (TH17) and at the same time promotes the generation of anti ...

One of the hallmarks of UC is a deficiency in certain bile acids (BAs), molecules that help digest fats and regulate gut health. These molecules are produced by the liver, and then further ...

Beyond its role in the initiation of digestion, the oral microbiome appears to be key to maintaining both oral and systemic ...

Bile is a body fluid produced by the liver that has a digestive and an excretion function. Bile could collect disease biomarkers released from the biliary tract or surrounding tissues, such as the ...

This important study analyzes the effect of heat treatment on phage-bacterial interactions and convincingly shows that prior heat exposure alters the bacterial cell envelope, enhancing persistence and ...

This predominance of small, dense LDL particles has been termed the atherogenic lipoprotein profile (ALP) and is linked to several metabolic issues that help explain its atherogenicity. [5] This ...

For decades, traditional affinity purification platforms like Protein A have been the cornerstone of monoclonal antibody manufacturing. However, the rise of engineered modalities – including ...

Modern structural analyses have revealed that these modifications significantly influence receptor binding affinity and specificity, particularly for key receptors such as FXR and TGR5 (2, 3). The ...

Protein A resin with high binding capacity for cost-efficient separation mAbs. MabSelect™ SuRe 70 protein A resin with high dynamic binding capacity (DBC), enables highly cost-efficient capture of ...