Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Age-related neurodegenerative disorders — motor neuron diseases, demyelinating diseases, Alzheimer’s disease, and other proteinopathies — are at an ‘inflection point.’ ...

Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary ...

Our liver is an important organ that helps to detoxify the body. So, it is our responsibility to feed it the right foods.

Researchers used Mendelian randomization to uncover causal links between gut microbiota, blood metabolites, and short stature ...

Mirum Pharmaceuticals, Inc. shows strong growth with a 43% revenue jump and promising pipeline assets. Click here for my ...

is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ligand-binding pocket (LBP ...

While it is understood that the drugs have also proven to be safe and effective for thousands, the negative issues have led ...

The total bile acids levels in the mice serum and fecal ... of Sev neurotoxicity through the regulation of microbial metabolism. “In our hospital, pediatric patients may experience medical ...