ECAR was measured under basal conditions followed by consecutive addition of glucose (10 mM) to induce glycolysis, oligomycin (1 μM) to inhibit ATP production in OXPHOS, and 2-DG ... supplemented with ...

Cells were lysed with RIPA buffer (Thermo Scientific) containing protease and phosphatase inhibitor (Roche ... and incubated overnight with OXPHOS (1:1000, Abcam, ab110413) and human beta-actin ...

Calcineurin inhibitors are topical and systemic immunosuppressants. They can help treat atopic dermatitis and autoimmune disorders such as lupus and psoriasis. They may also help prevent organ ...

Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis.

SGLT2 inhibitors are medications designed to help manage blood sugar in people living with type 2 diabetes. Learn more about the different types, as well as the benefits and side effects.

ORLANDO, Fla. — Of the 12 biologics in four drug classes approved for treating psoriasis in the United States, interleukin 23 (IL-23) inhibitors might be exceptional, particularly if used early ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bioenergetic requirements of muscle stem ...

Overall, both analyses of the HFpEF proteome independently highlight defects in protein translation, mitochondrial electron transport (OxPhos) and metabolic pathways, the latter most suppressed in the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aberrant mitochondrial function has been ...

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, International ...