Older adults with cancer respond just as well as younger patients to immune checkpoint inhibitors despite age-related immune ...

It remains unclear, however, which proportion of this increased risk can be attributed to the use of cytokine inhibitors, to the underlying disease, or to other immunosuppressive medications ...

A new implant safely triggers potent immune responses against hard-to-treat cancers showing "promise" for pancreatic and ...

Janus kinase (JAK) inhibitors: tofacitinib, filgotinib and upadacitinib. Cytokine inhibitors: ustekinumab, which targets interleukin (IL) 12, subunit p40/p35; risankizumab, mirikizumab ...

In addition to a greater risk for serious infection, patients with atopic dermatitis initiating JAK inhibitors vs Th2 cytokine inhibitors had a greater risk of Candida infections and a slightly ...

A team of researchers from the Rice Biotech Launch Pad at Rice University in Houston developed the implantable “cytokine ...

Cytokines have been the mainstay of treatment ... A large number of new small molecule inhibitors are emerging that have caused considerable interest in the oncology community.

Kanazawa University and colleagues have developed a promising new approach to cancer treatment. By using tiny, naturally ...

The IL-12 cytokine factories in combination with checkpoint inhibitors successfully eliminated local and distal tumors in preclinical models of metastatic melanoma and colorectal and pancreatic ...

Interest in cytokine modulation has expanded further with the success of interleukin (IL) inhibitors, as well as inhibitors of kinases involved in signalling downstream of cytokine receptors ...

IL-6 is a pro-inflammatory cytokine largely produced by macrophages. “The mechanism by which this occurs needs to be investigated,” they added. Taken together, these results suggest the dual role ...