A new study published in Cell provides a remarkably detailed characterization of gut epithelial enterochromaffin cells (ECs), showing that they are able to sense luminal metabolites, irritants and ...

Enterochromaffin cells (blue) in finger-like projections within the gut villi (outlined in red) detect noxious chemicals. Photo by Holly Ingraham/David Julius labs. Specialized cells in the gut sense ...

All the substances that stimulated enterochromaffin cells have been implicated in irritable bowel syndrome (IBS) – a condition involving alternating episodes of constipation and diarrhoea.

Moreover, the enterochromaffin cells likely mediate a selective response to SEA. This Tac1+-Hrt3a+-enterochromaffin circuit forms the gut-brain pathway that mediates defensive nausea, ...

The gene expression profile of metastasizing serotonin-producing neuroendocrine carcinomas, which arise from enterochromaffin cells in the jejunum and ileum, is still largely unknown. The aim of ...

Gut enterochromaffin cells regulate gut and bone homeostasis via serotonin production. A recent report suggested that gut microbes regulate serotonin levels, but the underlying molecular ...

The article ‘The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon’ by Kelsi N. Dodds, Lee Travis, Melinda ...

A rare cell type in the gut, the enterochromaffin (EC) cell, drove both gut discomfort and anxiety symptoms in animal models of gastrointestinal pain. Furthermore, the cells reacted differently in ...

T he infant gut is packed with a medley of molecules that dictate development during a critical time in a newborns’ life. But how these molecules interact with and influence immune cells early in life ...

Researchers review significant advancements and ongoing challenges in cell replacement therapies for type 1 diabetes, ... resembling serotonin-producing enterochromaffin cells, ...

David Julius et al. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell , June 2017 DOI: 10.1016/j.cell.2017.05.034 Cite This Page : ...