BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...

Edited by Wilfred van der Donk, University of Illinois at Urbana-Champaign, Urbana, IL; received November 27, 2024; accepted February 21, 2025 ...

Hepatocyte-restricted PPARα deletion impairs liver and whole-body fatty acid homeostasis. Hepatic PPARα responds to acute and chronic adipose tissue lipolysis. Hepatic PPARα regulates circadian ...

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL. (MF., Z.-D.G., M.D., C.L., K.G., S.E.W., E.B.T.) ...

State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pharmacology and Chemical ...

1 School of Public Health, Gansu University of Chinese Medicine, Lanzhou, China 2 College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China ...

Modular polyketide synthases (PKSs) play a vital role in the biosynthesis of complex natural products ... from murine fatty acid synthase serves as a highly versatile tool for the production ...

After the increased breakdown of peripheral adipose tissue in the body, the uptake of free fatty acids by hepatocytes increases and ... with DMEM containing FBS (negative control), OA-BSA complex (0.5 ...

Blocking MUFA generation by inhibition of stearoyl-CoA desaturases, which are enzymes required for the production of MUFAs from saturated fatty acids, reduced the proliferation and/or survival of ...

Mitochondrial fatty acid synthesis (FASII) and iron sulfur cluster (FeS ... ACP is a stable and essential subunit of the eukaryotic FeS biogenesis complex. In the absence of ACP, the complex is ...