Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

This was a mighty challenge. The cells kept dying. Paleontologist Kyoko Hagino of Kochi University tried for twelve years until she finally cracked it with a cousin of the original organism.

the FITC released by Lp reached the connecting lamina propria, which is a thin layer of connective tissue just below the epithelium. Importantly, FITC-labelled Lp was only detected in intestine ...

USA The intestinal barrier serves as a boundary between the mucosal immune system in the lamina propria and the external environment of the intestinal lumen, which contains a diverse array of ...

Conclusions GPR171 deficiency promotes Th17 cell differentiation and causes lipid metabolism perturbation, contributing to intestinal inflammation in a FABP5-dependent manner. Target therapy (eg, ...

They found that in UC patients, the lower levels of 7α-dehydroxylated bile acids strongly correlated with impaired intestinal cell renewal. This reinforces the link between bile acid metabolism ...

Sera were analysed for markers of intestinal cell damage and systemic immune response to microbial components. Results Individuals with wheat sensitivity had significantly increased serum levels of ...

Intestinal epithelial cells (IECs) are a mucosal immune barrier essential to coordinate host–microbe crosstalk. Sepsis is a systemic inflammatory syndrome with dysfunction in multiple organs including ...

As control animals, mice were injected with isotype antibody. Large intestinal lamina propria cells were isolated as previously described (14). Briefly, mouse intestines were washed in PBS, once with ...