ORLANDO, Fla. — Of the 12 biologics in four drug classes approved for treating psoriasis in the United States, interleukin 23 (IL-23) inhibitors might be exceptional, particularly if used early ...

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, International ...

Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis.

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People’s Republic of China Key Laboratory of Marine ...

Overall, both analyses of the HFpEF proteome independently highlight defects in protein translation, mitochondrial electron transport (OxPhos) and metabolic pathways, the latter most suppressed in the ...

Functionally, PA28γ contributes to the malignant progression of OSCC by affecting mitochondrial morphology and oxidative phosphorylation (OXPHOS) through C1QBP in vitro and vivo. Mechanically, PA28γ ...

Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer ...

A novel, allosteric and highly potent USP1 inhibitor, LAE120 exhibits robust tumor inhibitory activity across various xenograft models Significantly accelerated the progress of drug discovery ...

Arginine induces the chromatin remodeling via histone acetylation, which results in TEAD4 recruitment to TEA motifs present in >46% of the promoter/enhancer of OXPHOS genes with consequent gene ...

The Bcl2 inhibitor ABT737 triggers selective aggregation of p62 during ... In contrast, tumors addicted to OXPHOS exhibit high Mfn1/2-regulated fused mitochondria possessing elevated ATP, MMP, OCR, ...