Lipid bilayers in mammalian membranes can have a more asymmetric composition than previously thought, new research shows.

Lipid bilayers in mammalian membranes can have a more asymmetric composition than previously thought, new research shows.

First discovered as proteins found on synaptic vesicles and at the presynaptic plasma membrane ... to refer to the holding of two membranes within a bilayer’s distance of one another (<5 ...

Department of Bioengineering Technologies, Leijten Laboratory, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede 7522NB, The Netherlands ...

and ultimately leads to membrane rupture and cell death. Lipid peroxidation also generates toxic byproducts, including 4-hydroxynonenal (HNE) and malondialdehyde (MDA), which further damage proteins, ...

In this study, we performed an in-depth lipidomics analysis to identify lipids associated with injury and disease activity. Methods Plasma samples were collected from paediatric-onset multiple ...

Tolaasin II is an amphiphilic, membrane ... lipid regime were observed implying a mode of action based on membrane asymmetry stress in this time and concentration window. While the assembly of the ...

School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K. School of Chemistry, University of Leeds, Leeds ...

The matrix (MA) domain drives Gag onto the plasma membrane through electrostatic interactions ... into the MA-membrane interactions. Given that lipid composition determines the character of a bilayer, ...

We use atomistic and coarse-grained MD simulations to study the binding of PLY to cholesterol-rich membranes, the organization of lipids around the prepore and pore conformations of PLY, and the ...

Voltage-activated potassium (Kv) channels open to conduct K + ions in response to membrane depolarization ... However, structures for a voltage-activated ion channel in a lipid bilayer environment ...