Here, genetics combined with multi-omics analyses reveal an essential role of mitochondrial fatty acid oxidation (FAO ... CPT2 depletion reduces cellular acetyl-CoA level and protein acetylation of ...

Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, China National Demonstration Center for Experimental Environment and Resources Education, College of Environmental ...

Hepatocyte-restricted PPARα deletion impairs liver and whole-body fatty acid homeostasis. Hepatic PPARα responds to acute and chronic adipose tissue lipolysis. Hepatic PPARα regulates circadian ...

In this review, we summarize the core mechanisms of ferroptosis, emphasizing its intricate connections to lipid metabolism, including fatty acid synthesis ... ACSL4, Acyl-CoA Synthetase Long-chain ...

State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pharmacology and Chemical ...

This important study reveals that disrupting fatty acid metabolism in macrophages significantly restricts the growth of Mycobacterium tuberculosis, showing that impaired lipid processing triggers ...

Leveraging the power of nature for sustainable chemical synthesis ... that the promiscuous malonyl/acetyl-transferase domain (MAT) from murine fatty acid synthase serves as a highly versatile ...

Biochemical pathways of peroxisomal lipid synthesis and ... n-3 docosapentaenoic acid; ELOVL, fatty acid elongase; EPA, eicosapentaenoic acid; EtnGpl, ethanolamine glycerophospholipids; FADS, fatty ...

Mitochondrial fatty acid synthesis (FASII) and iron sulfur cluster (FeS) biogenesis are both vital biosynthetic processes within mitochondria. In this study, we demonstrate that the mitochondrial acyl ...