San Francisco 49ers running back Isaac Guerendo has been diagnosed with a sprained foot, head coach Kyle Shanahan announced on Monday. Ian Rapoport @RapSheet <a href ...

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

Good news for the 49ers. Rookie running back Isaac Guerendo is expected to play through a foot sprain tonight against the Los Angeles Rams, according to ESPN's Adam Schefter. Guerendo is the 49ers ...

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the remainder of the regular season. Well, Guerendo suffered an injury of his own ...

Will the San Francisco 49ers and fantasy football managers have Isaac Guerendo at their disposal for pivotal Week 15 matchups? Chicago Bears v San Francisco 49ers / Michael Zagaris/GettyImages If ...

The San Francisco 49ers' running backs just can't catch a break. Isaac Guerendo shined in his first career NFL start last week, shredding the Chicago Bears' defense with 128 total yards and two ...