Ms. Psaki, 46, will host a show at 9 p.m. Tuesday through Friday, replacing Alex Wagner, a longtime political journalist who has anchored that hour since 2022, according to a memo to staff from Rebecca Kutler, MSNBC’s president. Ms. Wagner will remain at MSNBC as an on-air correspondent.

Jen Psaki, the former Biden White House press secretary who has become a favorite at MSNBC since joining in 2023, will get even more screen time in front of viewers in April when she takes over the network's 9 p.

Network president Rebecca Kutler unveiled sweeping changes at MSNBC in prime time and weekends, with several shows canceled.