The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to Seattle.

Dramatic video shows a man being rescued on Sunday after dangling from the edge of a cliff in San Francisco, California. The California Highway Patrol helicopter responded to the scene as the man ...

Sean “Diddy" Combs' camp claims the feds raided his jail cell and took away “a bunch of privileged materials," according to a ...

Daniel Lurie joined KTVU on Monday to talk about his transition to become San Francisco's next mayor.

The San Francisco 49ers have injury issues at two of the most important positions on their roster entering Week 12. San Francisco 49ers head coach Kyle Shanahan spoke to reporters during a Monday ...

Following San Francisco’s last-minute loss to the Seattle Seahawks in Week 11, the 49ers received bad news about two of their team leaders ahead of their Week 12 matchup against the Green Bay Packers.

After falling to 5-5 with a disappointing 20-17 loss to the Seattle Seahawks on Sunday, the San Francisco 49ers received even ...

David Kelvin Santos, a muxe now living in San Francisco, continues this tradition with pride. "I buy dresses because I like ...

Matt Alexander appears poised to keep his job after eking out a victory over challenger John Jersin for the fourth and final ...

One of the reasons the San Francisco 49ers get touted as an amazing offense is because of Deebo Samuel. Well, he's been anything but amazing this season. Samuel ...

The Wu administration has wrapped up the third and final round of SPACE grants aimed at using $10 million in federal funds to support small businesses that are filling empty storefronts in downtown ...

American Christmas Tree Lighting’ on Friday, at 5 p.m. ET during a special edition of ‘The Five.’ Co-hosts Harold Ford Jr., Greg Gutfeld, Dana Perino, Judge Jeanine Pirro, Jessica Tarlov and Jesse ...