Sep 1, 2002 · The effective number of exploitable drug targets can be determined by the intersection of the number of genes linked to disease and the 'druggable' subset of the human …

The goal of the Illuminating the Druggable Genome (IDG) program is to improve our understanding of the properties and functions of proteins that are currently unannotated within …

The set of proteins with potential to be modulated by a drug-like small molecule has been predicted on the basis of sequence and structural similarity to the targets of existing drugs, the …

Sep 30, 2022 · Twenty years ago Hopkins and Groom (2002) published “The Druggable Genome.” This seminal paper recognised that only a subset of the newly published human …

Mar 29, 2017 · Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease biomarkers and disease …

A set of ten steps can help to define optimal candidates for pharmaceutical development based on human genetic association: (i) identify coincident associations between clinical endpoints and …

Mar 1, 2024 · This review lays out new resources developed by the IDG Program for the community. There are ∼4500 genes within the ‘druggable genome’, the subset of the human …

What is druggability? Definitions of ‘druggability’ vary: ‘the ability of a protein target to bind small molecules with high affinity’ - sometimes (perhaps more appropriately) called ‘ligandability’ …

Sep 30, 2022 · The concept of the druggable genome has been with us for 20 years. During this time, researchers have developed several methods and resources to help assess a target’s …

With only 10% of the human genome representing druggable targets, and only half of those being relevant to disease, it is important to be able to predict how druggable a novel target is in early...